The primary mission of the helicopter is AMCM, which includes minesweeping, mine neutralization, mine hunting, floating mine destruction, channel marking, and surface towing such as the towing of surface craft and ships. The secondary utility mission involves the movement of cargo and equipment and the transportation of passengers.
The MH-60S missions include Vertical Replenishment (VERTREP), Vertical Onboard Delivery (VOD), amphibious Search and Rescue (SAR), Non-combatant Evacuation Operations (NEO), Medical Evacuation (MEDEVAC), Special Warfare Support, Combat Search and Rescue (CSAR), Maritime Interdiction Operations (MIO), Anti-surface Warfare (SUW), CV Plane Guard/SAR, Air Ambulance, and Organic Airborne Mine Countermeasures (OAMCM).
The MH-60R primary missions include Surface Warfare (SUW) and Anti-Submarine Warfare (ASW). Eight secondary missions are also assigned to the aircraft. These include Search and Rescue (SAR), Medical Evacuation (MEDEVAC), Vertical Replenishment (VERTREP), Naval Surface Fire Support (NSFS), Communications Relay (COMREL), Command, Control, Communications (CCC), Command and Control Warfare (C2W), and Non-Combat Operations (NCO).